Primary choroidal melanoma followed by two metachronous ipsilateral ocular metastases

Purpose . To describe two ipsilateral, metachronous, ocular choroidal melanoma metastases. Material and methods A 64-year-old patient was initially treated with palladium-103 ophthalmic plaque brachytherapy which induced local control of the primary cancer. Seven years later, findings a second, discrete prompted restaging revealed new hepatic nodal Systemic immunotherapy (ipilimumab 3 mg/kg nivolumab 1 IV every weeks 4 doses) resulted in intraocular tumor regression followed by maintenance 480 mg follow-up examinations. Results Three after initiation systemic immunotherapy, found to have second ipsilateral recurrence melanoma. It presented retinal detachment, uveitis, optic neuritis. Then, due its anterior uveal location, extrascleral extension amenable diagnostic biopsy. Overall, onset metastatic 2 months her metastasis, died. This 10 initial diagnosis Conclusions Metastatic can present twice same eye as tumor. Ophthalmic examinations allowed for affect regression, vision sparing, globe salvage.